Therapeutically targeting essential metabolites to improve immunometabolism manipulation after liver transplantation for hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most prevalent primary liver malignancy worldwide and associated with a poor prognosis. Sophisticated molecular mechanisms biological characteristics need to be explored gain better understanding of HCC. The role metabolites in cancer immunometabolism has been widely recognized as hallmark tumor microenvironment (TME). Recent studies have focused on that are derived from carbohydrate, lipid, protein metabolism, because alterations these may contribute HCC progression, ischemia-reperfusion (IR) injury during transplantation (LT), post-LT rejection. Immune cells play central duration IR or They shape immune responses through metabolite modifications by engaging complex crosstalk cells. A growing number publications suggest cell functions TME closely linked metabolic changes. In this review, we summarize recent findings metabolism relate development, injury, Our aberrant targeting based regulatory pathways provide novel strategy enhance manipulation reprogramming metabolism.